Genome Medicine | Volume 1 Issue 3

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		Volume 1 Issue 3
		Comment
		Editorial Sharing knowledge: a new frontier for public-private partnerships in medicine Charles Auffray Genome Medicine 2009, 1:29 (4 March 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary It is time to redefine the frontier between what can be the subject matter of valuable intellectual property rights and the basic knowledge that should be made freely available to all.
		Musings Musings on genome medicine: the Obama effect David G Nathan, Stuart H Orkin Genome Medicine 2009, 1:30 (9 March 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The inauguration of the Obama administration brings with it shaky optimisim about the future of genome medicine in clinical care and national economics.
		Review
		Review *Applications of metabolomics and proteomics to the mdx* mouse model of Duchenne muscular dystrophy: lessons from downstream of the transcriptome** Julian L Griffin, Christine Des Rosiers Genome Medicine 2009, 1:32 (25 March 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An overview of developments in the proteomics, metabolomics and fluxomics of Duchenne muscular dystrophy using the mdx mouse model highlights new insights into the disease process as well as into the basic biology of the cell.
		Review Genetics of Alzheimer's disease: recent advances Dimitrios Avramopoulos Genome Medicine 2009, 1:34 (27 March 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary New genome-wide association studies are now yielding results that may add to our knowledge of the genetics of Alzheimers disease and may improve our understanding of the biological pathways leading to disease.
		Review Integrating post-genomic approaches as a strategy to advance our understanding of health and disease Jing Tang, Chong Tan, Matej Oresic, Antonio Vidal-Puig Genome Medicine 2009, 1:35 (30 March 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary While the challenges of integrating very different types of data and perspectives of disease into a global model suitable for dissecting disease mechanisms and predicting therapeutic strategies are great, models based upon multiple datasets will become the basis that drives future research.
		Minireview Narrowing down the role of common variants in the genetic predisposition to obesity Melissa A Calton, Christian Vaisse Genome Medicine 2009, 1:31 (11 March 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Two recent genome-wide association studies have found that common variants within at least eleven genes are associated with obesity, but the contribution of rare variants remains to be elucidated.
		Minireview Chipping away at the common epilepsies with complex genetics: the 15q13.3 microdeletion shows the way John C Mulley, Leanne M Dibbens Genome Medicine 2009, 1:33 (25 March 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The discovery of a chromosome 15q13.3 microdeletion barely scratches the surface of the molecular genetic mechanisms behind the common epilepsies with complex genetics, but it provides valuable insight into how to proceed toward that goal.