Next-generation personalized drug discovery: the tripeptide GHK hits center stage in chronic obstructive pulmonary disease
Comprehensive Pneumology Center, University Hospital of the Ludwig-Maximilians-University Munich and Helmholtz Zentrum München, Member of the German Center for Lung Research, Max-Lebsche-Platz 31, D-81377 Munich, Germany
Genome Medicine 2012, 4:70 doi:10.1186/gm371Published: 21 September 2012
Chronic lung diseases (CLDs), including chronic obstructive pulmonary disease (COPD), are the second leading cause of death worldwide. The first report of database-driven drug discovery in carefully phenotyped COPD specimens has now been published in Genome Medicine, combining gene expression data in defined emphysematous areas with connectivity-map-based compound discovery. This joint effort may lead the way to novel and potentially more efficient concepts of personalized drug discovery for COPD in particular, and CLD in general.