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Look, no hands! Spectral biomarkers from genetic association studies

Michael Inouye* and Gad Abraham

Author Affiliations

Medical Systems Biology, Department of Pathology and Department of Microbiology & Immunology, The University of Melbourne, Parkville, Victoria 3010, Australia

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Genome Medicine 2013, 5:14  doi:10.1186/gm418

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Published: 15 February 2013


Recent advances in our understanding of the genomics of the human metabolome have shed light on the pathways involved in metabolic and cardiovascular disease. Such studies crucially depend on the interpretation of complex molecular spectra. A recent study by Suhre and colleagues provides a way to identify potentially clinically relevant biomarkers without a priori information, such as reference spectra, thus aiding the discovery of additional spectral features and corresponding genomic loci associated with metabolism and disease.