Medicine in the post-genomic era

Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.


  • Rebecca Furlong, PhD,


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  • Image attributed to: From Fig 1 Pelletier and colleagues

    DNA-PK inhibition boosts Cas9-mediated HDR

    Transient pharmacological inhibition of DNA-PKcs can stimulate homology-directed repair following Cas9-mediated induction of a double strand break, and is expected to reduce the downstream workload.

    Genome Medicine 2015, 7:93
  • Genomics of epilepsy

    Candace Myers and Heather Mefford review how advances in genomic technologies have aided genome-wide discovery of both common and rare variants, leading to a rapid increase in our understanding of epilepsy genetics and avenues for therapy.

    Genome Medicine 2015, 7:91
  • Image attributed to: From Fig 2 Everson et al.

    CpG sites associated with atopy

    Thirteen novel epigenetic loci associated with atopy and high IgE were found that could serve 55 as candidate loci; of these, four were within genes with known roles in the immune response.

    Genome Medicine 2015, 7:89
  • Image attributed to: From Fig 2 Gorringe and colleagues

    Ovarian cancer landscape

    Exome sequencing of mucinous ovarian carcinoma tumors reveals multiple mutational targets, suggesting tumors arise through many routes, and shows  this group of tumors is distinct from other subtypes.

    Genome Medicine 2015, 7:87
  • Image attributed to: From Fig 4 Van Allen and colleagues

    NGS-guided cancer therapy

    Jeffrey Gagan and Eliezer Van Allen review how next-generation sequencing can be incorporated into standard oncology clinical practice and provide guidance on the potential and limitations of sequencing.

    Genome Medicine 2015, 7:80
  • Image attributed to: From Fig 3 Chen and colleagues


    A platform for managing clinical exome sequencing data that includes data entry, distribution of work assignments, variant evaluation and review, selection of variants for validation, report generation.

    Genome Medicine 2015, 7:77
  • Image attributed to: By apple2000

    Semantic workflow for clinical omics

    A clinical omics analysis pipeline using the Workflow Instance Generation and Specialization (WINGS) semantic workflow platform demonstrates transparency, reproducibility and analytical validity.

    Genome Medicine 2015, 7:73
  • Image attributed to: From Figure 5_Varadan et al

    Detection of somatic copy number alteration

    A novel framework for detection of somatic copy number alterations across WES platforms identifies mutational landscape and genomic aberrations in African American colon cancers.

    Genome Medicine 2015, 7:69

Featured review

In search of new treatment for chronic painIn search of new treatment for chronic pain

Stephen McMahon and colleagues review treatments for pain relief, which are often inadequate, and discuss how understanding of the genomic and epigenomic mechanisms might lead to improved drugs.

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call for papers: Diagnostic Genomics
call for papers: immunogenomics in health and disease
Open access reviews
Variant calling


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Article collections

  • Diagnostic genomics
    Edited by: Prof James Lupski, Dr Joris Veltman
    Published: 1 July 2015
    Last updated: 13 August 2015

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ISSN: 1756-994X