Medicine in the post-genomic era

Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.


  • Rebecca Furlong, PhD,


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  • Image attributed to: Blood sample from a neonate via wikimedia

    26-hour whole genome sequencing

    A new rapid medical whole genome sequencing protocol with a time to result of 26 hours and greater than 99.5% sensitivity and specificity for nucleotide variants.

    Genome Medicine 2015, 7:100
  • Image attributed to: nanopore schematic from authors figure 1

    Real-time nanopore pathogen detection

    Unbiased metagenomic analysis using a real-time MinION pipeline allows detection of chikungunya, ebola, and hepatitis C viruses.

    Genome Medicine 2015, 7:99
  • Image attributed to: CDC (PHIL #6670), 1976

    Pre-antibiotic reference collection

    Julian Parkhill and colleagues announce the public availability of the Murray Enterobacteriaceae collection, with metadata and whole genome sequence analyses.

    Genome Medicine 2015, 7:97
  • Image attributed to: CFTR figure 1

    Therapeutic strategies for cystic fibrosis

    Malcolm Brodlie, Stuart Elborn and colleagues discuss precision medicine approaches to improve function of the cystic fibrosis transmembrane receptor protein.

    Genome Medicine 2015, 7:101
  • Image attributed to: Cornish figure 1

    Mapping diseases to cells

    Integration of PPI data with cell-type-specific gene expression data identifies known disease–cell-type associations and highlights new associations for further study.

    Genome Medicine 2015, 7:95
  • Image attributed to: From Fig 1 Pelletier and colleagues

    DNA-PK inhibition boosts Cas9-mediated HDR

    Transient pharmacological inhibition of DNA-PKcs can stimulate homology-directed repair following Cas9-mediated induction of a double strand break, and is expected to reduce the downstream workload.

    Genome Medicine 2015, 7:93
  • Genomics of epilepsy

    Candace Myers and Heather Mefford review how advances in genomic technologies have aided variant discovery, leading to a rapid increase in our understanding of epilepsy genetics.

    Genome Medicine 2015, 7:91
  • Image attributed to: From Fig 2 Everson et al.

    CpG sites associated with atopy

    Thirteen novel epigenetic loci associated with atopy and high IgE were found that could serve 55 as candidate loci; of these, four were within genes with known roles in the immune response.

    Genome Medicine 2015, 7:89

Featured review

In search of new treatment for chronic painIn search of new treatment for chronic pain

Stephen McMahon and colleagues review treatments for pain relief, which are often inadequate, and discuss how understanding of the genomic and epigenomic mechanisms might lead to improved drugs.

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Translating the Microbiome: call for papers
call for papers: Diagnostic Genomics
call for papers: immunogenomics in health and disease
Open access reviews
Variant calling


Participatory medicine

podcast logo As part of our article series on Participatory Medicine, check out the free podcast featuring Lee Hood, Mike Snyder, and Kim Norris.

Article collections

  • Diagnostic genomics
    Edited by: Dr Joris Veltman, Prof James Lupski
    Published: 1 July 2015
    Last updated: 30 September 2015

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ISSN: 1756-994X