Medicine in the post-genomic era
Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.
- Rebecca Furlong, PhD,
A novel analytical approach that allows extraction of T cell receptor sequence information directly from RNA sequencing data and that can be used to characterize tumor-associated T cell repertoires.
Longitudinal analysis of the B cell receptor repertoire after immunization with a new influenza virus strain reveals unique features in clonal structure, IGHV segment use and low somatic hypermutation levels.
A new method based on high-throughput sequencing of the TCR locus of a large cohort of healthy individuals reveals functional and non-functional alleles of individual TCRβ V gene segments.
Transcriptional analysis of naïve and polarized T cells integrating three different approaches reveals a high-confidence list of Th1 and Th2 lineage-specific protein-coding genes and long non-coding RNAs.
Gur Yaari and Steven Kleinstein provide practical guidelines for B-cell receptor (BCR) repertoire sequencing (Rep-seq) analysis, along with recommendations for avoiding common problems.
Eran Elinav and colleagues review advances in understanding the regulatory interplay between the host intestinal immune system and the gut microbial metagenome.
Linus Backert and Oliver Kohlbacher compare strengths and weaknesses of computational tools for T- and B-cell epitope prediction and discuss new challenges and opportunities presented by big data.
An interactive user interface to explore a large collection of cell lines and extract information about HLA type, predicted neo-antigens, expressed viruses and gene expression.
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