Medicine in the post-genomic era
Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.
- Rebecca Furlong, PhD,
A new rapid medical whole genome sequencing protocol with a time to result of 26 hours and greater than 99.5% sensitivity and specificity for nucleotide variants.
Unbiased metagenomic analysis using a real-time MinION pipeline allows detection of chikungunya, ebola, and hepatitis C viruses.
Julian Parkhill and colleagues announce the public availability of the Murray Enterobacteriaceae collection, with metadata and whole genome sequence analyses.
Malcolm Brodlie, Stuart Elborn and colleagues discuss precision medicine approaches to improve function of the cystic fibrosis transmembrane receptor protein.
Integration of PPI data with cell-type-specific gene expression data identifies known disease–cell-type associations and highlights new associations for further study.
Transient pharmacological inhibition of DNA-PKcs can stimulate homology-directed repair following Cas9-mediated induction of a double strand break, and is expected to reduce the downstream workload.
Candace Myers and Heather Mefford review how advances in genomic technologies have aided variant discovery, leading to a rapid increase in our understanding of epilepsy genetics.
Thirteen novel epigenetic loci associated with atopy and high IgE were found that could serve 55 as candidate loci; of these, four were within genes with known roles in the immune response.
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