Medicine in the post-genomic era

Genome Medicine publishes peer-reviewed research articles, new methods, software tools, reviews and comment articles in all areas of medicine studied from a post-genomic perspective. Areas covered include, but are not limited to, disease genomics (including genome-wide association studies and sequencing-based studies), disease epigenomics, pathogen and microbiome genomics, immunogenomics, translational genomics, pharmacogenomics and personalized medicine, proteomics and metabolomics in medicine, systems medicine, and ethical, legal and social issues.


  • Rebecca Furlong, PhD,


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  • Image attributed to: Detail of Figure 1 from Brown et al.

    Extracting TCR repertoires from RNA-seq data

    A novel analytical approach that allows extraction of T cell receptor sequence information directly from RNA sequencing data and that can be used to characterize tumor-associated T cell repertoires.

    Genome Medicine 2015, 7:125
  • Image attributed to: Influenza virus_from iStockPhoto

    B cell Rep-seq sheds light on Influenza immunity

    Longitudinal analysis of the B cell receptor repertoire after immunization with a new influenza virus strain reveals unique features in clonal structure, IGHV segment use and low somatic hypermutation levels.

    Genome Medicine 2015, 7:124
  • Image attributed to: Detail of Figure 4 from Dean et al.

    Annotation of TCR pseudogenic gene segments

    A new method based on high-throughput sequencing of the TCR locus of a large cohort of healthy individuals reveals functional and non-functional alleles of individual TCRβ V gene segments.

    Genome Medicine 2015, 7:123
  • Image attributed to: Detail of Figure 3 from Kanduri et al.

    Novel Th cell lineage-specific genes and lncRNAs

    Transcriptional analysis of naïve and polarized T cells integrating three different approaches reveals a high-confidence list of Th1 and Th2 lineage-specific protein-coding genes and long non-coding RNAs.

    Genome Medicine 2015, 7:122
  • Image attributed to: Figure 1, flowchart of steps in BCR Rep-seq analysis

    Guidelines for BCR Rep-seq analysis

    Gur Yaari and Steven Kleinstein provide practical guidelines for B-cell receptor (BCR) repertoire sequencing (Rep-seq) analysis, along with recommendations for avoiding common problems.

    Genome Medicine 2015, 7:121
  • Image attributed to: Fig 2, schematic showing effects of immune system on metagenome

    Immunogenome-microbiome crosstalk

    Eran Elinav and colleagues review advances in understanding the regulatory interplay between the host intestinal immune system and the gut microbial metagenome.

    Genome Medicine 2015, 7:120
  • Image attributed to: Laptop computer_from iStockPhoto

    Computational tools for epitope prediction

    Linus Backert and Oliver Kohlbacher compare strengths and weaknesses of computational tools for T- and B-cell epitope prediction and discuss new challenges and opportunities presented by big data.

    Genome Medicine 2015, 7:119
  • Image attributed to: Detail of Figure 1 from Scholtalbers et al.

    TCLP: a large cancer line interactive catalogue

    An interactive user interface to explore a large collection of cell lines and extract information about HLA type, predicted neo-antigens, expressed viruses and gene expression.

    Genome Medicine 2015, 7:118

Featured review

In search of new treatment for chronic painIn search of new treatment for chronic pain

Stephen McMahon and colleagues review treatments for pain relief, which are often inadequate, and discuss how understanding of the genomic and epigenomic mechanisms might lead to improved drugs.

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ISSN: 1756-994X