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Guide for Genome Medicine reviewers
This guide for reviewers contains information about basic considerations that should be applied when reviewing a manuscript that has been submitted to Genome Medicine, and about the editorial standards of the journal. Other relevant information about the journal’s aims and scope and editorial policies can be found at 'About this journal'.
Submitted manuscripts are usually reviewed by two or more experts. Peer reviewers will be asked to recommend whether a manuscript should be accepted, revised or rejected. They should also alert the editors of any issues relating to author misconduct such as plagiarism and unethical behavior.
Genome Medicine operates using a closed peer review system.
Publication of research articles by Genome Medicine is dependent primarily on their validity and coherence, as judged by peer reviewers and editors. The reviewers may also be asked whether the writing is comprehensible and how interesting they consider the article to be. Genome Medicine aims to publish only the most interesting articles and these quality requirements should be taken into consideration when indicating your overall rating for the manuscript. Submitted manuscripts will be sent to peer reviewers, unless they are out of scope or below the interest threshold of Genome Medicine, or if the presentation or written English is of an unacceptably low standard.
Points to consider
Reviewers are asked to provide detailed, constructive comments that will help the editors make a decision on publication and the author(s) improve their manuscript. A key issue is whether the work has serious flaws that should preclude its publication, or whether there are additional experiments or data required to support the conclusions drawn. Where possible, reviewers should provide references to substantiate their comments.
Reviewers should address the points below and indicate whether they consider any required revisions to be 'major compulsory revisions', 'minor essential revisions' or 'discretionary revisions'. In general, revisions are likely to be 'Major compulsory revisions' if additional controls are required to support the claims or the interpretations are not supported by the data, if further analysis is required that may change the conclusions, or if the methods used are inadequate or statistical errors have been made.
- Is the question posed original, important and well defined?
The research question posed by the authors should be easily identifiable and understood.
It is useful to both the editors and authors if reviewers comment on the originality and importance of the study within the context of its field. If the research question is unoriginal because related work has been published previously, please give references.
Reviewers should ask themselves after reading the manuscript if they have learnt something new and if there is a clear conclusion from the study.
- Are the data sound and well controlled?
If you feel that inappropriate controls have been used please say so, indicating the reasons for your concerns, and suggesting alternative controls where appropriate. If you feel that further experimental/clinical evidence is required to substantiate the results, please provide details.
- Is the interpretation (discussion and conclusion) well balanced and supported by the data?
The interpretation should discuss the relevance of all the results in an unbiased manner. Are the interpretations overly positive or negative?
Conclusions drawn from the study should be valid and result directly from the data shown, with reference to other relevant work as applicable. Have the authors provided references wherever necessary?
- Are the methods appropriate and well described, and are sufficient details provided to allow others to evaluate and/or replicate the work?
Please remark on the suitability of the methods for the study, which should be clearly described and reproducible by peers in the field.
If statistical analyses have been carried out, specify whether or not they need to be assessed specifically by an additional reviewer with statistical expertise.
- What are the strengths and weaknesses of the methods?
Please comment on any improvements that could be made to the study design to enhance the quality of the results. If any additional experiments are required, please give details.
If novel experimental techniques were used please pay special attention to their reliability and validity.
- Can the writing, organization, tables and figures be improved?
Although the editorial team may also assess the quality of the written English, please do comment if you consider the standard is below that expected for a scientific publication.
If the manuscript is organized in such a manner that it is illogical or not easily accessible to the reader please suggest improvements.
Please provide feedback on whether the data are presented in the most appropriate manner; for example, is a table being used where a graph would give increased clarity? Do the figures appear to be genuine, i.e. without evidence of manipulation, and of a high enough quality to be published in their present form?
- When revisions are requested.
Reviewers may recommend revisions for any or all of the following reasons: data need to be added to support the authors' conclusions; better justification is needed for the arguments based on existing data; or the clarity and/or coherence of the paper needs to be improved.
- Are there any ethical or competing interests issues you would like to raise?
The study should adhere to ethical standards of scientific/medical research and the authors should declare that they have received ethics approval and or patient consent for the study, where appropriate.
Whilst we do not expect reviewers to delve into authors' competing interests, if you are aware of any issues that you do not think have been adequately addressed, please inform the editorial office.
- Reviewers are reminded of the importance of timely reviews.
If reviewers encounter or foresee any problems meeting the deadline for a report, they should contact firstname.lastname@example.org.
Any manuscript sent for peer review is a confidential document and should remain so until it is formally published.
- Are the included additional files (supplementary materials) appropriate?
Online publishing enables the inclusion of additional files with published articles. Additional files of many types can be submitted, including movies, tabular data and mini-websites. Reviewers are encouraged to comment on the appropriateness of the types of additional files, included with the manuscript, for publication with the final article. Additional files pertaining to original/raw data files that support the results reported in the manuscript can be included. It is not expected that reviewers should reanalyze all supporting data as part of their peer review, but the availability of supporting data enables more detailed investigation of particular aspects of the study if the reviewer or editor feels it is necessary.
Portability of peer review
To support efficient and thorough peer review, we aim to reduce the number of times a manuscript is reviewed, thereby speeding up the publication process and reducing the burden on peer reviewers. Therefore, please note that, if a manuscript is not accepted for publication in Genome Medicine and the authors choose to submit a revised version to another BioMed Central published journal, we will pass the reviews on to the other journal's editors at the authors’ request. We will reveal the reviewers' names to the handling editor for editorial purposes unless reviewers let us know when they return their report that they do not wish us to share their report with another BioMed Central published journal and/or that they do not wish to participate further in the peer review of this manuscript.
Reviewers are asked to bear the editorial standards of Genome Medicine in mind and alert the editors if authors have not fully adhered to them. Genome Medicine is a member of the Committee on Publication Ethics (COPE).
Standards of reporting
Genome Medicine supports initiatives aimed at improving the reporting of research. Reviewers can find more details on this at Standards of Reporting in 'About Genome Medicine'.