PTPN22 splice forms: a new role in rheumatoid arthritis
Instituto de Parasitología y Biomedicina López-Neyra, CSIC (IPBLN-CSIC), Parque Tecnológico Ciencias de la Salud, Avenida del Conocimiento s/n 18100, Armilla, Granada, Spain
Genome Medicine 2012, 4:13 doi:10.1186/gm312Published: 24 February 2012
Genetic variation in the protein tyrosine phosphatase non-receptor type gene 22 (PTPN22, encoding lymphoid tyrosine phosphatase, LYP) influences the risk of developing multiple autoimmune diseases, but the underlying mechanisms are not completely understood. In a recent study published in Genome Medicine, Ronninger et al. showed that there are differences in the expression of PTPN22 isoforms between peripheral blood mononuclear cells from rheumatoid arthritis patients and those of healthy controls. This study provides new insights into the role of PTPN22 in autoimmune diseases.